2025 NDC/HCPCS Crosswalk


The NDC/HCPCS crosswalk provides a listing of each National Drug Code that is assigned to a HCPCS. The crosswalk is updated monthly, but contains all prior updates, along with providing details on what changes occurred that month.

For NDC/HCPCS crosswalk questions or file layout, view our NDC Crosswalk Questions and Answers.

April 2025

NDC to HCPCS Crosswalk (Excel, 1142 KB)
NDC to HCPCS Crosswalk (PDF, 2759 KB)
Date Changes (PDF, 25 KB)
Coding Changes (PDF, 36 KB)
Conversion Factor Changes (PDF, 10 KB)
Records and NDCs Added (PDF, 53 KB)
Records and NDCs Removed (PDF, 12 KB)
Additional Changes (PDF, 9 KB)

March 2025

NDC to HCPCS Crosswalk (Excel, 1122 KB)
NDC to HCPCS Crosswalk (PDF, 2721 KB)
Date Changes (PDF, 17 KB)
Coding Changes (PDF, 9 KB)
Conversion Factor Changes (PDF, 10 KB)
Records and NDCs Added (PDF, 24 KB)
Records and NDCs Removed (PDF, 13 KB)
Additional Changes (PDF, 9 KB)

February 2025

NDC to HCPCS Crosswalk (Excel, 1119 KB)
NDC to HCPCS Crosswalk (PDF, 2714 KB)
Date Changes (PDF, 17 KB)
Coding Changes (PDF, 9 KB)
Conversion Factor Changes (PDF, 10 KB)
Records and NDCs Added (PDF, 25 KB)
Records and NDCs Removed (PDF, 11 KB)
Additional Changes (PDF, 9 KB)

January 2025

NDC to HCPCS Crosswalk (Excel, 1121 KB)
NDC to HCPCS Crosswalk (PDF, 2709 KB)
Date Changes (PDF, 19 KB)
Coding Changes (PDF, 45 KB)
Conversion Factor Changes (PDF, 10 KB)
Records and NDCs Added (PDF, 65 KB)
Records and NDCs Removed (PDF, 17 KB)
Additional Changes (PDF, 9 KB)

Last Updated: 03/28/2025